Neurophysiological monitoring has a history of over 30 years and has been widely used in surgery for spinal cord, skull base, functional area tumors and epilepsy.
#MEPS WAKE UP TIME TRIAL#
The study registered on the Chinese Clinical Trial Registry ( Clinical Trials identifier ChiCTR2100045504 (). All patients studied had normal neurological examination findings, hence, these results may not be applicable to patients with preexisting deficits.
#MEPS WAKE UP TIME MAC#
At the same MAC concentration, desflurane appeared to have a stronger inhibitory effect than sevoflurane. SEPs and MEPs were inhibited in a dose-dependent manner by both desflurane and sevoflurane. The MEP amplitudes in the desflurane group were significantly lower than those in the sevoflurane group ( P < 0.05), only the amplitudes of the upper limbs at 0.3 MAC did not vary significantly. The SEP latencies of both the upper and lower limbs in the desflurane group were significantly longer, and the SEP amplitudes were significantly lower than those in the sevoflurane group ( P < 0.05). In each desflurane or sevoflurane group, the amplitudes of SEPs and MEPs decreased and the latencies of SEPs were prolonged significantly as the MAC increased ( P < 0.05). SEP and MEP signals were well preserved in patients who underwent neurosurgery under general anesthesia supplemented with desflurane or sevoflurane at concentrations of 0.3, 0.6 and 0.9 MAC. Multiples levels (concentrations of 0.3, 0.6 and 0.9) of anesthetics were administered at minimum alveolar concentration (MAC), and then the latencies and amplitudes of SEPs and MEPs were recorded. MethodsĪ total of 40 consecutive patients undergoing neurosurgery were randomly assigned to two groups receiving inhaled anesthetics, either desflurane or sevoflurane. However, some studies have showed that inhaled halogenated anesthetics have a significant impact on neurophysiological monitoring. Better protection can be provided during neurosurgery due to the establishment of somatosensory-evoked potential (SEP) and motor-evoked potential (MEP) monitoring technologies.
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